遗传?/a>机制不清楚?/p>
我们采用DNA芯片、DNA序列分析、基因组文库构徏和{基因动物{方法,比较人类和非人灵长类大脑认知功能区(如前额叶区)(j)基因表达的差异;探讨在灵长类大脑发育中v关键作用基因和基因家族的分子演化模式和规律?/p>
另一斚wQ我们还开展对人类h和史前迁徙的分子考古学研I。采用古DNA分析的方法对人类化石和遗骸进行研IӞ探烦(ch)东亚Cv源的方式Q重建其史前q徙的\U,?jin)解人类体遗传l构的历史变q及(qing)其与人群文化、语a分化以及(qing)人类遗传疄的关pR?/p>
q期研究NQ?/p>
1.人类和非人灵长类大脑前额叶学?fn)、记忆功能区基因表达q研究?/p>
2. 人类和非人灵长类大脑快速进化基因的研究?/p>
3. 东亚Cv源和史前q徙的研I?/p>
4.灵长cd因组文库的构Z灵长cd因组的演化研I?/p>
5.人类中枢经pȝ疄的遗传学基础研究?/p>
团队成员Q?/p>
目前Q实验室共有研究人员14人,其中博士?人,士?人,技术员1人?/p>
q期发表论文Q?/p>
Wang YQQ?Su B. 2004 Molecular evolution of microcephalinQ?a gene determining human brain size. Human Molecular Genetics Qin pressQ?/p>
QianQ?YPQ?Jin LQ?Su B. 2004 Construction and characterization of bacterial artificial chromosome library of black-handed spider monkey QAteles geoffroyiQ?Genome 47Q?39-245.
Xu HL.Q?Qian YP.Q?Nie WH.Q?Chi JX.Q?Yang FT.Q?Su B. 2004 ConstructionQ?characterization and chromosomal mapping of bacterial artificial chromosome QBACQ?library of Yunnan snub-nosed monkey QRhinopithecus bietiQ?Chromosome Research 12Q?51-262.
LellQ?JT.Q?SukernikQ?RI.Q?StarikovskayaQ?YB.Q?Su B. et al. 2002 The dual origin and Siberian affinities of Native American Y chromosomes. American Journal of Human Genetics 70Q?92-206.
Wells RSQ?Yuldasheva NYQ?Ruzibakiev RMQ?Underhill PAQ?Evseeva IQ?Blue-Smith JQ?Jin LQ?SuQ?B. et al. 2001 The Eurasian heartlandQA continental perspective on Y-chromosome diversity. PNAS 98Q?0244-10249.
Ke YHQ?Su B.Qco-first authorQ?et al. 2001 No independent origin of modern humans in East AsiaQ?a tale of 12Q?00 Y chromosomes. Science 292Q?151-1153.
Ramana GVQ?Su B et al. 2001 Y chromosome SNP haplotypes suggest evidence of gene flow among casteQ?tribeQ?and the migrant Siddi populations of Andhra PradeshQ?South India. Eur. J. Hum Genet. 9Q?95-700
SuQ?B et al. 2001 Genetic diversity and population history in Red Panda QAilurus fulgensQ?as inferred from mitochondrial DNA sequence variations. Molecular Biology and Evolution 18Q?070-1076.
AkeyQ?J.M.QSosnoskiQ?D.QParraQ?E.QDiosQ?S.QHiesterQ?K.QSuQ?B. et al. 2001
Melting Curve Analysis of SNPs QMcSNPQ:(x) A Gel-Free and Inexpensive Approach for SNP Genotyping. BioTechniques 30Q?58-367
KeQ?YH.Q?SuQ?B et al. 2001 Y-chromosome haplotype distribution in Han Chinese populatiions and modern human origin in East Asians. Science in China QSeries CQ?44Q?25-232.
KeQ?YH.Q?SuQ?B et al. 2001 Y-chromosome evidence for no independent origin of modern human in China. Chinese Science Bulletin 46Q?35-937.
SuQ?B et al. 2000 Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Human Genetics 107Q?82-590
SuQ?B et al. 2000 Distributions of three HIV-1 resistant polymorphisms QSDF1-3''AQ?CCR2-64IQ?and CCR5-Q?2Q?in Global Populations. European Journal of Human Genetics 8Q?39-945
SuQ?B et al. 2000 Polynesian OriginsQ?New Insights from the Y-chromosome PNASQ?USA 97Q?225-8228
Jin L and Su B. 2000 Natives or ImmgrantsQ?Modern human origin in East Asia. Nature Reviews Genetics 1Q?26-133.
Qian YPQ?Qian BZQ?Su B. 2000 Multiple Origins of TibetanQ?Y Chromosome Evidences. Human Genetics 106Q?53-454
PetersonQ?B.Q?SuQ?B et al.Q?2000 World population data for the HLA-DQA1QPM and D1S80 loci with least and most common profile frequencies for combinations of loci estimated following NRC II guidelines. Journal of Forensic Science. 45 Q?Q:(x)118-146
SuQ?B et al. 1999 Y Chromosome evidence for a Northward Migration of Modern Humans into East Asia during the Last Ice Age. American Journal of Human Genetics 65Q?718-1724
SuQ?B et al. 1999 Distribution of two HIV-1 polymorphisms QSDF1-3‘A and CCR2-64IQ?in East Asia and world populations and its implication in AIDS epidemiology. American Journal of Human Genetics 65Q?047-1053
SuQ?B et al. 1999 Phylogenetic study of complete cytochrome b genes of musk deer Qgenus MoschusQ?using museum samples. Molecular Phylogentics and Evolution 12Q?41-249
ChakrabortyQ?R.Q?StiversQ?DN. and SuQ?B et al.Q?1999 The utility of short tandem repeat loci beyond human identificationQ?Implications for development of new DNA typing systems. Electrophresis 20Q?682-1696
SuQ?B et al. 1998 Frequency of an HIV-resistant allele is exceptionally high in New Guinea Highlanders. Journal of the American Medical AssociationQ?JAMA. 280Q?830
联系信息Q?/p>
?sh)话Q?871Q?120202 Q实验室Q;0871Q?120212Q办公室Q?/p>
EmailQsub@mail.kiz.ac.cn ?bing.su@uc.edu
地址Q昆明市(jng)教场东\32号中国科学院昆明动物研究所
邮编Q?50223
实验室网:(x)http://159.226.149.98/compgenegroup/compgenegroup.htm
?中科院昆明动物研I所